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Can the AMD Instinct MI300X run Qwen3 Coder 480B-A35B?

63Good quality (B) · 63 of 100: how capable the model is at Q2_K, whatever it runs on. Match score 68/100 (quality, fit, speed and memory use) sets the ranking.

Yes, it runs well (offloads to RAM)

Runs well (offloads to RAM). At Q2_K it needs about 204 GB of 192 GB usable, with an estimated speed of 42.7 tok/s.

Best quant
Q2_K
Generation speed
42.7 tok/s
Prompt processing
2,764 tok/s
First token (1K prompt)
0.4 s
Largest safe context
—

Best app to run it on the AMD Instinct MI300X

On Linux

llama.cpp

Command line + local API · runs on llama.cpp

  • Splits the model between GPU memory and system RAM, which this setup needs.
  • Gives you direct control of how many layers sit on the GPU, the best way to squeeze a model that doesn’t quite fit.
  • Usually the first to support new model architectures.
llama-server -hf unsloth/Qwen3-Coder-480B-A35B-Instruct-GGUF:Q2_K
  • LM Studio Splits the model between GPU memory and system RAM, which this setup needs.
  • Lemonade Splits the model between GPU memory and system RAM, which this setup needs.

On Windows

llama.cpp

Command line + local API · runs on llama.cpp

  • Splits the model between GPU memory and system RAM, which this setup needs.
  • Gives you direct control of how many layers sit on the GPU, the best way to squeeze a model that doesn’t quite fit.
  • Usually the first to support new model architectures.
llama-server -hf unsloth/Qwen3-Coder-480B-A35B-Instruct-GGUF:Q2_K
  • LM Studio Splits the model between GPU memory and system RAM, which this setup needs.
  • Lemonade Splits the model between GPU memory and system RAM, which this setup needs.

Want an agent? Qwen3 Coder 480B-A35B supports tool use, so you can pair a llama.cpp or MLX LM server with one of these. Apps that run on this computer come first.

Coding agents

Personal assistants

How we choose: the files published for this model, your operating system and GPU, whether it fits fully in memory, and published speed tests (MLX vs llama.cpp on Apple silicon, vLLM vs llama.cpp vs Ollama on NVIDIA). Details.

Download Qwen3 Coder 480B-A35B

Recommended for the AMD Instinct MI300X: Q2_K. Every other quantization has its own download link in the table below.

Quickest · Ollama

One command downloads a ready-to-run version and starts a chat.

Get Ollama at ollama.com/download (opens in a new tab) · model page (opens in a new tab)

ollama run qwen3-coder:480b

Quantized files · GGUF

Works in LM Studio, llama.cpp, Jan and Ollama. No sign-in needed.

Download the Q2_K files (opens in a new tab)

huggingface.co/unsloth/Qwen3-Coder-480B-A35B-Instruct-GGUF (opens in a new tab)

ollama run hf.co/unsloth/Qwen3-Coder-480B-A35B-Instruct-GGUF

Original weights · Hugging Face

Full-precision files from Alibaba, for fine-tuning, vLLM, Transformers.

huggingface.co/Qwen/Qwen3-Coder-480B-A35B-Instruct (opens in a new tab)

No sign-in needed.

Official repo · GitHub

Reference code, inference scripts and docs from Alibaba. The weights themselves download from Hugging Face.

github.com/QwenLM/Qwen3-Coder (opens in a new tab)

Qwen’s coder repo, renamed from Qwen2.5-Coder to Qwen3-Coder.

git clone https://github.com/QwenLM/Qwen3-Coder

Links checked 1 day ago against Hugging Face, Ollama and GitHub.

How it’s rated

Quality 63Good quality (B) · 63 of 100: how capable the model is at Q2_K, whatever it runs on. Match score 68/100 (quality, fit, speed and memory use) sets the ranking.
How capable the model itself is at Q2_K, from its editorial quality tier scaled by the quantization or precision. It’s the same on any hardware that runs this variant. Scale: A+ 85+ · A 70+ · B 55+ · C 40+ · D under 40.
Runs Runs welloffloads to RAM
How well it runs on the AMD Instinct MI300X: speed, capped by how well it fits in memory. Runs great: 30+ tokens/s (or near the image, video or decision speed target) · Runs well: 10+ tokens/s · Slow: 3+ tokens/s · Very slow: under 3 · Won’t run: doesn’t fit even with offload. A tight fit or RAM offload caps it at Runs well; heavy offload caps it at Slow.

Match score

To order lists, each result also gets a match score out of 100 from four parts. It favors the most capable model that still runs well.

Model qualityEditorial quality tier of the model, scaled by the quantization or precision used.28.7 / 45
Memory fitFull marks when everything sits in GPU memory; fewer when part spills to system RAM.10.0 / 25
SpeedGeneration speed against a 40 tokens/s target for LLMs, or render time against a target for image and video.15.0 / 15
Memory useRewards using the memory you have, so a bigger, better variant beats a tiny one that leaves most memory idle.15.0 / 15
Match score68.7 / 100

The match score orders results; it is not shown as a grade. Quality and Runs are the two ratings in the tables.

Every quantization on the AMD Instinct MI300X

Quant Memory needed Available Speed Runs Quality Download
Q2_K 204 GB 192 GB 42.7 tok/s Runs welloffloads to RAM 63Good quality (B) · 63 of 100: how capable the model is at Q2_K, whatever it runs on. Match score 68/100 (quality, fit, speed and memory use) sets the ranking. GGUF · folder (opens in a new tab)
Q3_K_M 248 GB 192 GB — Won't run 76Great quality (A) · 76 of 100: how capable the model is at Q3_K_M, whatever it runs on. Match score 10/100 (quality, fit, speed and memory use) sets the ranking. GGUF · folder (opens in a new tab)
Q4_K_M 305 GB 192 GB — Won't run 86Excellent quality (A+) · 86 of 100: how capable the model is at Q4_K_M, whatever it runs on. Match score 11/100 (quality, fit, speed and memory use) sets the ranking. GGUF · folder (opens in a new tab)
Q5_K_M 353 GB 192 GB — Won't run 88Excellent quality (A+) · 88 of 100: how capable the model is at Q5_K_M, whatever it runs on. Match score 11/100 (quality, fit, speed and memory use) sets the ranking. GGUF · folder (opens in a new tab)
Q6_K 406 GB 192 GB — Won't run 90Excellent quality (A+) · 90 of 100: how capable the model is at Q6_K, whatever it runs on. Match score 12/100 (quality, fit, speed and memory use) sets the ranking. GGUF · folder (opens in a new tab)
Q8_0 521 GB 192 GB — Won't run 91Excellent quality (A+) · 91 of 100: how capable the model is at Q8_0, whatever it runs on. Match score 12/100 (quality, fit, speed and memory use) sets the ranking. GGUF · folder (opens in a new tab)
F16 973 GB 192 GB — Won't run 91Excellent quality (A+) · 91 of 100: how capable the model is at F16, whatever it runs on. Match score 12/100 (quality, fit, speed and memory use) sets the ranking. GGUF · folder (opens in a new tab) Original weights (opens in a new tab)

Memory figures assume 8K of context. Longer conversations or documents grow the KV cache.

Other hardware that runs it

Estimates come from published hardware specs and our open formulas, not from running the model on your machine. Real speed varies with runtime, drivers and settings. Numbers marked “Measured” come from a linked benchmark.

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