Llama 3.1 Nemotron Ultra 253B v1 on AMD Instinct MI350X

Can the AMD Instinct MI350X run Llama 3.1 Nemotron Ultra 253B v1?

Yes, it runs great

Runs great. At Q4_K_M it needs about 174 GB of 288 GB usable, with an estimated speed of 33.4 tok/s.

Best quant: Q4_K_M
Generation speed: 33.4 tok/s
Prompt processing: 335 tok/s
First token (1K prompt): 3.1 s
Largest safe context: 128K

Best app to run it on the AMD Instinct MI350X

On Linux

vLLM

Inference server · runs on vLLM

The full model fits in GPU memory at 8-bit, so it can batch many requests: best for serving a team or an app.

vllm serve nvidia/Llama-3_1-Nemotron-Ultra-253B-v1

Lemonade AMD’s own app: llama.cpp tuned for Radeon on Vulkan and ROCm.
LM Studio Point-and-click: search, download and chat in one window.

On Windows

Lemonade

Desktop app · runs on llama.cpp, ONNX Runtime GenAI (Ryzen AI NPU)

AMD’s own app: llama.cpp tuned for Radeon on Vulkan and ROCm.

lemonade pull unsloth/Llama-3_1-Nemotron-Ultra-253B-v1-GGUF:Q4_K_M

LM Studio Point-and-click: search, download and chat in one window.
llama.cpp Usually the first to support new model architectures.

Want an agent? Llama 3.1 Nemotron Ultra 253B v1 supports tool use, so you can pair a llama.cpp or MLX LM server with one of these. Apps that run on this computer come first.

Coding agents

Personal assistants

How we choose: the files published for this model, your operating system and GPU, whether it fits fully in memory, and published speed tests (MLX vs llama.cpp on Apple silicon, vLLM vs llama.cpp vs Ollama on NVIDIA). Details.

Download Llama 3.1 Nemotron Ultra 253B v1

Recommended for the AMD Instinct MI350X: Q4_K_M. Every other quantization has its own download link in the table below.

Quantized files · GGUF

Works in LM Studio, llama.cpp, Jan and Ollama. No sign-in needed.

Download the Q4_K_M files (opens in a new tab)

huggingface.co/unsloth/Llama-3_1-Nemotron-Ultra-253B-v1-GGUF (opens in a new tab)

ollama run hf.co/unsloth/Llama-3_1-Nemotron-Ultra-253B-v1-GGUF

Original weights · Hugging Face

Full-precision files from NVIDIA, for fine-tuning, vLLM, Transformers.

huggingface.co/nvidia/Llama-3_1-Nemotron-Ultra-253B-v1 (opens in a new tab)

No sign-in needed.

Links checked 1 day ago against Hugging Face, Ollama and GitHub.

How it’s rated

Quality 81Great quality (A) · 81 of 100: how capable the model is at Q4_K_M, whatever it runs on. Match score 89/100 (quality, fit, speed and memory use) sets the ranking.: How capable the model itself is at Q4_K_M, from its editorial quality tier scaled by the quantization or precision. It’s the same on any hardware that runs this variant. Scale: A+ 85+ · A 70+ · B 55+ · C 40+ · D under 40.
Runs Runs great: How well it runs on the AMD Instinct MI350X: speed, capped by how well it fits in memory. Runs great: 30+ tokens/s (or near the image, video or decision speed target) · Runs well: 10+ tokens/s · Slow: 3+ tokens/s · Very slow: under 3 · Won’t run: doesn’t fit even with offload. A tight fit or RAM offload caps it at Runs well; heavy offload caps it at Slow.

Match score

To order lists, each result also gets a match score out of 100 from four parts. It favors the most capable model that still runs well.

Model qualityEditorial quality tier of the model, scaled by the quantization or precision used.	36.8 / 45
Memory fitFull marks when everything sits in GPU memory; fewer when part spills to system RAM.	25.0 / 25
SpeedGeneration speed against a 40 tokens/s target for LLMs, or render time against a target for image and video.	13.7 / 15
Memory useRewards using the memory you have, so a bigger, better variant beats a tiny one that leaves most memory idle.	13.9 / 15
Match score	89.4 / 100

The match score orders results; it is not shown as a grade. Quality and Runs are the two ratings in the tables.

Every quantization on the AMD Instinct MI350X

Quant	Memory needed	Available	Speed	Runs	Quality	Download
`Q2_K`	121 GB	288 GB	54.8 tok/s	Runs great	60Good quality (B) · 60 of 100: how capable the model is at Q2_K, whatever it runs on. Match score 76/100 (quality, fit, speed and memory use) sets the ranking.	GGUF · folder (opens in a new tab)
`Q3_K_M`	143 GB	288 GB	43.1 tok/s	Runs great	72Great quality (A) · 72 of 100: how capable the model is at Q3_K_M, whatever it runs on. Match score 83/100 (quality, fit, speed and memory use) sets the ranking.	GGUF · folder (opens in a new tab)
`Q4_K_M`	174 GB	288 GB	33.4 tok/s	Runs great	81Great quality (A) · 81 of 100: how capable the model is at Q4_K_M, whatever it runs on. Match score 89/100 (quality, fit, speed and memory use) sets the ranking.	GGUF · folder (opens in a new tab)
`Q5_K_M`	199 GB	288 GB	27.6 tok/s	Runs well	83Great quality (A) · 83 of 100: how capable the model is at Q5_K_M, whatever it runs on. Match score 89/100 (quality, fit, speed and memory use) sets the ranking.	GGUF · folder (opens in a new tab)
`Q6_K`	227 GB	288 GB	23.2 tok/s	Runs well	85Excellent quality (A+) · 85 of 100: how capable the model is at Q6_K, whatever it runs on. Match score 89/100 (quality, fit, speed and memory use) sets the ranking.	GGUF · folder (opens in a new tab)
`Q8_0`	288 GB	288 GB	17.0 tok/s	Runs welltight fit	86Excellent quality (A+) · 86 of 100: how capable the model is at Q8_0, whatever it runs on. Match score 87/100 (quality, fit, speed and memory use) sets the ranking.	GGUF · folder (opens in a new tab)
`F16`	526 GB	288 GB	—	Won't run	86Excellent quality (A+) · 86 of 100: how capable the model is at F16, whatever it runs on. Match score 11/100 (quality, fit, speed and memory use) sets the ranking.	GGUF · folder (opens in a new tab) Original weights (opens in a new tab)

Memory figures assume 8K of context. Longer conversations or documents grow the KV cache.

Other hardware that runs it

81Great quality (A) · 81 of 100: how capable the model is at Q4_K_M, whatever it runs on. Match score 90/100 (quality, fit, speed and memory use) sets the ranking. NVIDIA GB300 Grace Blackwell Ultra Desktop Superchip Q4_K_M · 34.4 tok/s · Runs great
81Great quality (A) · 81 of 100: how capable the model is at Q4_K_M, whatever it runs on. Match score 90/100 (quality, fit, speed and memory use) sets the ranking. NVIDIA B200 Q4_K_M · 38.8 tok/s · Runs well (tight fit)
81Great quality (A) · 81 of 100: how capable the model is at Q4_K_M, whatever it runs on. Match score 88/100 (quality, fit, speed and memory use) sets the ranking. AMD Instinct MI325X Q4_K_M · 25.0 tok/s · Runs well
81Great quality (A) · 81 of 100: how capable the model is at Q4_K_M, whatever it runs on. Match score 86/100 (quality, fit, speed and memory use) sets the ranking. AMD Instinct MI300X Q4_K_M · 22.1 tok/s · Runs well (tight fit)
72Great quality (A) · 72 of 100: how capable the model is at Q3_K_M, whatever it runs on. Match score 84/100 (quality, fit, speed and memory use) sets the ranking. NVIDIA H200 141GB SXM Q3_K_M · 30.1 tok/s · Runs well (tight fit)
72Great quality (A) · 72 of 100: how capable the model is at Q3_K_M, whatever it runs on. Match score 84/100 (quality, fit, speed and memory use) sets the ranking. NVIDIA H200 NVL Q3_K_M · 30.1 tok/s · Runs well (tight fit)

Estimates come from published hardware specs and our open formulas, not from running the model on your machine. Real speed varies with runtime, drivers and settings. Numbers marked “Measured” come from a linked benchmark.