Intern-S2 (397B-A17B) on AMD Instinct MI350X

Can the AMD Instinct MI350X run Intern-S2 (397B-A17B)?

Yes, it runs well (tight fit)

Runs well (tight fit). At Q4_K_M it needs about 261 GB of 288 GB usable, with an estimated speed of 186 tok/s.

Best quant: Q4_K_M
Generation speed: 186 tok/s
Prompt processing: 4,996 tok/s
First token (1K prompt): 0.3 s
Largest safe context: 256K

Best app to run it on the AMD Instinct MI350X

On Linux

Lemonade

Desktop app · runs on llama.cpp, ONNX Runtime GenAI (Ryzen AI NPU)

AMD’s own app: llama.cpp tuned for Radeon on Vulkan and ROCm.

lemonade pull bartowski/Intern-S2-397B-GGUF:Q4_K_M

LM Studio Point-and-click: search, download and chat in one window.
llama.cpp Usually the first to support new model architectures.

On Windows

Lemonade

Desktop app · runs on llama.cpp, ONNX Runtime GenAI (Ryzen AI NPU)

AMD’s own app: llama.cpp tuned for Radeon on Vulkan and ROCm.

lemonade pull bartowski/Intern-S2-397B-GGUF:Q4_K_M

LM Studio Point-and-click: search, download and chat in one window.
llama.cpp Usually the first to support new model architectures.

Want an agent? Intern-S2 (397B-A17B) supports tool use, so you can pair a llama.cpp or MLX LM server with one of these. Apps that run on this computer come first.

Coding agents

Personal assistants

How we choose: the files published for this model, your operating system and GPU, whether it fits fully in memory, and published speed tests (MLX vs llama.cpp on Apple silicon, vLLM vs llama.cpp vs Ollama on NVIDIA). Details.

Download Intern-S2 (397B-A17B)

Recommended for the AMD Instinct MI350X: Q4_K_M. Every other quantization has its own download link in the table below.

Quantized files · GGUF

Works in LM Studio, llama.cpp, Jan and Ollama. No sign-in needed.

Download the Q4_K_M files (opens in a new tab)

huggingface.co/bartowski/Intern-S2-397B-GGUF (opens in a new tab)

ollama run hf.co/bartowski/Intern-S2-397B-GGUF

Original weights · Hugging Face

Full-precision files from Shanghai AI Lab, for fine-tuning, vLLM, Transformers.

huggingface.co/internlm/Intern-S2-397B (opens in a new tab)

No sign-in needed.

Official repo · GitHub

Reference code, inference scripts and docs from Shanghai AI Lab. The weights themselves download from Hugging Face.

github.com/InternLM/Intern-S1 (opens in a new tab)

The model card links to the Intern-S1 repo, which also covers Intern-S2.

git clone https://github.com/InternLM/Intern-S1

Links checked 1 day ago against Hugging Face, Ollama and GitHub.

How it’s rated

Quality 90Excellent quality (A+) · 90 of 100: how capable the model is at Q4_K_M, whatever it runs on. Match score 94/100 (quality, fit, speed and memory use) sets the ranking.: How capable the model itself is at Q4_K_M, from its editorial quality tier scaled by the quantization or precision. It’s the same on any hardware that runs this variant. Scale: A+ 85+ · A 70+ · B 55+ · C 40+ · D under 40.
Runs Runs welltight fit: How well it runs on the AMD Instinct MI350X: speed, capped by how well it fits in memory. Runs great: 30+ tokens/s (or near the image, video or decision speed target) · Runs well: 10+ tokens/s · Slow: 3+ tokens/s · Very slow: under 3 · Won’t run: doesn’t fit even with offload. A tight fit or RAM offload caps it at Runs well; heavy offload caps it at Slow.

Match score

To order lists, each result also gets a match score out of 100 from four parts. It favors the most capable model that still runs well.

Model qualityEditorial quality tier of the model, scaled by the quantization or precision used.	40.7 / 45
Memory fitFull marks when everything sits in GPU memory; fewer when part spills to system RAM.	24.0 / 25
SpeedGeneration speed against a 40 tokens/s target for LLMs, or render time against a target for image and video.	15.0 / 15
Memory useRewards using the memory you have, so a bigger, better variant beats a tiny one that leaves most memory idle.	15.0 / 15
Match score	94.7 / 100

The match score orders results; it is not shown as a grade. Quality and Runs are the two ratings in the tables.

Every quantization on the AMD Instinct MI350X

Quant	Memory needed	Available	Speed	Runs	Quality	Download
`Q2_K`	177 GB	288 GB	230 tok/s	Runs great	66Good quality (B) · 66 of 100: how capable the model is at Q2_K, whatever it runs on. Match score 84/100 (quality, fit, speed and memory use) sets the ranking.	GGUF · folder (opens in a new tab)
`Q3_K_M`	213 GB	288 GB	209 tok/s	Runs great	80Great quality (A) · 80 of 100: how capable the model is at Q3_K_M, whatever it runs on. Match score 91/100 (quality, fit, speed and memory use) sets the ranking.	GGUF · folder (opens in a new tab)
`Q4_K_M`	261 GB	288 GB	186 tok/s	Runs welltight fit	90Excellent quality (A+) · 90 of 100: how capable the model is at Q4_K_M, whatever it runs on. Match score 94/100 (quality, fit, speed and memory use) sets the ranking.	GGUF · folder (opens in a new tab)
`Q5_K_M`	302 GB	288 GB	56.1 tok/s	Runs welloffloads to RAM	92Excellent quality (A+) · 92 of 100: how capable the model is at Q5_K_M, whatever it runs on. Match score 81/100 (quality, fit, speed and memory use) sets the ranking.	GGUF · folder (opens in a new tab)
`Q6_K`	346 GB	288 GB	—	Won't run	94Excellent quality (A+) · 94 of 100: how capable the model is at Q6_K, whatever it runs on. Match score 12/100 (quality, fit, speed and memory use) sets the ranking.	GGUF · folder (opens in a new tab)
`Q8_0`	443 GB	288 GB	—	Won't run	95Excellent quality (A+) · 95 of 100: how capable the model is at Q8_0, whatever it runs on. Match score 12/100 (quality, fit, speed and memory use) sets the ranking.	GGUF · folder (opens in a new tab)
`F16`	822 GB	288 GB	—	Won't run	95Excellent quality (A+) · 95 of 100: how capable the model is at F16, whatever it runs on. Match score 12/100 (quality, fit, speed and memory use) sets the ranking.	Original weights (opens in a new tab)

Memory figures assume 8K of context. Longer conversations or documents grow the KV cache.

Other hardware that runs it

92Excellent quality (A+) · 92 of 100: how capable the model is at Q5_K_M, whatever it runs on. Match score 95/100 (quality, fit, speed and memory use) sets the ranking. Apple M3 Ultra (512 GB) Q5_K_M · 36.7 tok/s · Runs great
66Good quality (B) · 66 of 100: how capable the model is at Q2_K, whatever it runs on. Match score 84/100 (quality, fit, speed and memory use) sets the ranking. Apple M3 Ultra (256 GB) Q2_K · 66.3 tok/s · Runs well (tight fit)
92Excellent quality (A+) · 92 of 100: how capable the model is at Q5_K_M, whatever it runs on. Match score 96/100 (quality, fit, speed and memory use) sets the ranking. Apple M5 Ultra (512 GB) Q5_K_M · 50.7 tok/s · Runs great
80Great quality (A) · 80 of 100: how capable the model is at Q3_K_M, whatever it runs on. Match score 91/100 (quality, fit, speed and memory use) sets the ranking. AMD Instinct MI325X Q3_K_M · 188 tok/s · Runs great
80Great quality (A) · 80 of 100: how capable the model is at Q3_K_M, whatever it runs on. Match score 91/100 (quality, fit, speed and memory use) sets the ranking. NVIDIA GB300 Grace Blackwell Ultra Desktop Superchip Q3_K_M · 211 tok/s · Runs great
66Good quality (B) · 66 of 100: how capable the model is at Q2_K, whatever it runs on. Match score 84/100 (quality, fit, speed and memory use) sets the ranking. AMD Instinct MI300X Q2_K · 201 tok/s · Runs well (tight fit)

Estimates come from published hardware specs and our open formulas, not from running the model on your machine. Real speed varies with runtime, drivers and settings. Numbers marked “Measured” come from a linked benchmark.