on

Can the AMD Instinct MI350X run Hermes 4 405B?

76Great quality (A) · 76 of 100: how capable the model is at Q4_K_M, whatever it runs on. Match score 84/100 (quality, fit, speed and memory use) sets the ranking.

Yes, it runs well (tight fit)

Runs well (tight fit). At Q4_K_M it needs about 267 GB of 288 GB usable, with an estimated speed of 20.8 tok/s.

Best quant
Q4_K_M
Generation speed
20.8 tok/s
Prompt processing
209 tok/s
First token (1K prompt)
4.9 s
Largest safe context
48K

Best app to run it on the AMD Instinct MI350X

On Linux

Lemonade

Desktop app · runs on llama.cpp, ONNX Runtime GenAI (Ryzen AI NPU)

  • AMD’s own app: llama.cpp tuned for Radeon on Vulkan and ROCm.
lemonade pull unsloth/Hermes-4-405B-GGUF:Q4_K_M
  • LM Studio Point-and-click: search, download and chat in one window.
  • llama.cpp Usually the first to support new model architectures.

On Windows

Lemonade

Desktop app · runs on llama.cpp, ONNX Runtime GenAI (Ryzen AI NPU)

  • AMD’s own app: llama.cpp tuned for Radeon on Vulkan and ROCm.
lemonade pull unsloth/Hermes-4-405B-GGUF:Q4_K_M
  • LM Studio Point-and-click: search, download and chat in one window.
  • llama.cpp Usually the first to support new model architectures.

Want an agent? Hermes 4 405B supports tool use, so you can pair a llama.cpp or MLX LM server with one of these. Apps that run on this computer come first.

Coding agents

Personal assistants

How we choose: the files published for this model, your operating system and GPU, whether it fits fully in memory, and published speed tests (MLX vs llama.cpp on Apple silicon, vLLM vs llama.cpp vs Ollama on NVIDIA). Details.

Download Hermes 4 405B

Recommended for the AMD Instinct MI350X: Q4_K_M. Every other quantization has its own download link in the table below.

Quantized files · GGUF

Works in LM Studio, llama.cpp, Jan and Ollama. No sign-in needed.

Download the Q4_K_M files (opens in a new tab)

huggingface.co/unsloth/Hermes-4-405B-GGUF (opens in a new tab)

ollama run hf.co/unsloth/Hermes-4-405B-GGUF

Original weights · Hugging Face

Full-precision files from Nous Research, for fine-tuning, vLLM, Transformers.

huggingface.co/NousResearch/Hermes-4-405B (opens in a new tab)

No sign-in needed.

Links checked 1 day ago against Hugging Face, Ollama and GitHub.

How it’s rated

Quality 76Great quality (A) · 76 of 100: how capable the model is at Q4_K_M, whatever it runs on. Match score 84/100 (quality, fit, speed and memory use) sets the ranking.
How capable the model itself is at Q4_K_M, from its editorial quality tier scaled by the quantization or precision. It’s the same on any hardware that runs this variant. Scale: A+ 85+ · A 70+ · B 55+ · C 40+ · D under 40.
Runs Runs welltight fit
How well it runs on the AMD Instinct MI350X: speed, capped by how well it fits in memory. Runs great: 30+ tokens/s (or near the image, video or decision speed target) · Runs well: 10+ tokens/s · Slow: 3+ tokens/s · Very slow: under 3 · Won’t run: doesn’t fit even with offload. A tight fit or RAM offload caps it at Runs well; heavy offload caps it at Slow.

Match score

To order lists, each result also gets a match score out of 100 from four parts. It favors the most capable model that still runs well.

Model qualityEditorial quality tier of the model, scaled by the quantization or precision used.34.2 / 45
Memory fitFull marks when everything sits in GPU memory; fewer when part spills to system RAM.24.0 / 25
SpeedGeneration speed against a 40 tokens/s target for LLMs, or render time against a target for image and video.10.8 / 15
Memory useRewards using the memory you have, so a bigger, better variant beats a tiny one that leaves most memory idle.15.0 / 15
Match score84.0 / 100

The match score orders results; it is not shown as a grade. Quality and Runs are the two ratings in the tables.

Every quantization on the AMD Instinct MI350X

Quant Memory needed Available Speed Runs Quality Download
Q2_K 182 GB 288 GB 34.2 tok/s Runs great 56Good quality (B) · 56 of 100: how capable the model is at Q2_K, whatever it runs on. Match score 78/100 (quality, fit, speed and memory use) sets the ranking. GGUF (UD-Q2_K_XL) · folder (opens in a new tab)
Q3_K_M 218 GB 288 GB 26.9 tok/s Runs well 67Good quality (B) · 67 of 100: how capable the model is at Q3_K_M, whatever it runs on. Match score 82/100 (quality, fit, speed and memory use) sets the ranking. GGUF (UD-Q3_K_XL) · folder (opens in a new tab)
Q4_K_M 267 GB 288 GB 20.8 tok/s Runs welltight fit 76Great quality (A) · 76 of 100: how capable the model is at Q4_K_M, whatever it runs on. Match score 84/100 (quality, fit, speed and memory use) sets the ranking. GGUF · folder (opens in a new tab)
Q5_K_M 307 GB 288 GB 2.2 tok/s Very slowoffloads to RAM 77Great quality (A) · 77 of 100: how capable the model is at Q5_K_M, whatever it runs on. Match score 63/100 (quality, fit, speed and memory use) sets the ranking. GGUF (UD-Q5_K_XL) · folder (opens in a new tab)
Q6_K 352 GB 288 GB — Won't run 79Great quality (A) · 79 of 100: how capable the model is at Q6_K, whatever it runs on. Match score 10/100 (quality, fit, speed and memory use) sets the ranking. GGUF files (opens in a new tab)
Q8_0 449 GB 288 GB — Won't run 80Great quality (A) · 80 of 100: how capable the model is at Q8_0, whatever it runs on. Match score 10/100 (quality, fit, speed and memory use) sets the ranking. GGUF · folder (opens in a new tab)
F16 831 GB 288 GB — Won't run 80Great quality (A) · 80 of 100: how capable the model is at F16, whatever it runs on. Match score 10/100 (quality, fit, speed and memory use) sets the ranking. GGUF · folder (opens in a new tab) Original weights (opens in a new tab)

Memory figures assume 8K of context. Longer conversations or documents grow the KV cache.

Other hardware that runs it

Estimates come from published hardware specs and our open formulas, not from running the model on your machine. Real speed varies with runtime, drivers and settings. Numbers marked “Measured” come from a linked benchmark.

Was this page helpful?